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Modern-day intravenous nutrition is preceded by an interesting history founded in wild experimentation, survival, and necessary supplementation. IV and injectable nutrition therapies remain a popular wellness treatment that both patients and physicians regularly inquire about. Despite sporadic, informal, and superficial clinical data, common IV nutrition protocols continue to evolve as part of a group of wellness-related medical treatments that remain in high demand. In fact, infusing or injecting specific micronutrients or nutritional solutions is not a new therapy. Parenteral nutrition use goes back to the early 20th century, while the basic IV administration of fluids and electrolytes began in the 1800s.

A major step toward a better understanding of parenteral nutrition occurred during the early 20th century, when infusions of glucose, plasma, and emulsified fat into humans became possible.
During the 1930s and 1940s, a clinical surgery professor at Washington University named Dr. Robert Elman observed that amino acids can be intravenously infused when delivered in the form of protein hydrolysates, peptides, and isolated amino acids. Prior to this, our knowledge of amino acid metabolism accumulated over time, but our understanding of the effects of specific amino acids and proteins in humans began to accelerate with Elman’s discoveries, along with the work of many others researching protein metabolism in previous years. In 1948, Elman concluded that the “use of parenteral amino acid mixtures enables the physician to treat disease without protein starvation.”